Journal article
Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces
CD Eiber, SC Payne, NP Biscola, LA Havton, JR Keast, PB Osborne, JB Fallon
Journal of Neural Engineering | Published : 2021
Abstract
Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective translation requires increasing the efficacy and predictability of neural interface performance. Here we use computational models of rat visceral nerve to predict how neuroanatomical variability could affect both electrical stimulation and recording with an experimental planar neural interface. Approach. We developed a hybrid computational pipeline, Visceral Nerve Ensemble Recording and Stimulation (ViNERS), to couple finite-element modelling of extracellular electrical fields with biophysical simulations of individual axons. Anatomical properties of fascicles and..
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Awarded by NIH Office of the Director
Funding Acknowledgements
This work was supported by the National Institutes of Health, Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program under Award Number OT2OD023872 (J K, P O, and J F) and OT2OD026585 (L H). The content of this work is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. L H also acknowledges support from the Dr Miriam and Sheldon G Adelson Medical Research Foundation. We would like to acknowledge Kiyotada Naito for surgical assistance; Alex Thompson for technical assistance with electrical equipment; Ross Thomas for the manufacture and refinement of the array design; Amy Morley and Erin Smyth for assistance and support conducting electrophysiology experiments; JingYang Liu and Eric Musselman for beta-testing the modelling pipeline; and John-Paul Fuller-Jackson, Nicole Wiedmann, and Ankita George for assisting with pelvic nerve sample preparation, perfusions, and tissue washes. We would also like to acknowledge Dr Matt Ward for intellectual input on some of the research concepts and selection of model outputs.